Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 3 reviews

No studies found 9 · 37.5%GRADE not reported 0 · 0%Very low 4 · 16.7%Low 3 · 12.5%Moderate 7 · 29.2%High 1 · 4.2%

Oral midazolam vs chloral hydrate

Level of sedation on a sedation assessment scale · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…
1 finding from 1 review

Oral midazolam vs chloral hydrate

Incomplete procedure · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

Oral midazolam probably leads to higher incomplete procedures compared with chloral hydrate (moderate certainty).

1 finding from 1 review

Oral midazolam vs chloral hydrate

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Disinhibition or excitation · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Patient discomfort · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Allergic or anaphylactoid reaction · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Level of sedation on a sedation assessment scale · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Anxiety · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Incomplete procedure · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Disinhibition or excitation · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Discomfort/pain · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Allergic or anaphylactoid reaction · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) probably leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (moderate certainty).

1 finding from 1 review