What do systematic reviews say?

Oral iron vs placebo or no treatment

The review found no eligible studies for this question.

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral iron vs placebo or no treatment

Oral iron showed no clear difference in clinical malaria compared with placebo or no treatment (high certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.93 [0.87, 1]
  14 studies · 7168 participants
  High

Oral iron vs placebo or no treatment

Oral iron showed no clear difference in clinical malaria Subgrouped by population anaemia (trial level) compared with placebo or no treatment (moderate certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.84, 1]
  14 studies · 7168 participants
  Moderate

Oral iron vs placebo or no treatment

Oral iron leads to lower severe malaria Defined as clinical malaria with high‐grade… compared with placebo or no treatment (high certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.9 [0.81, 0.98]
  6 studies · 3421 participants
  High

Oral iron vs placebo or no treatment

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 7576 participants
  Low

Oral iron vs placebo or no treatment

It is very uncertain whether oral iron changes hospitalization plus clinic visits compared with placebo or no treatment (very low certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.99 [0.95, 1.04]
  6 studies · 12578 participants
  Very low

Oral iron with antimalarial prophylaxis vs placebo or no treatment

Oral iron with antimalarial prophylaxis showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 1.05 [0.52, 2.11]
  728 participants
  Low

Oral iron with antimalarial prophylaxis vs placebo or no treatment

Oral iron with antimalarial prophylaxis leads to lower clinical malaria compared with placebo or no treatment (high certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.54 [0.43, 0.67]
  728 participants
  High

Intervention not reported

The review found no eligible studies for this question.

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention may leads to lower clinical malaria Subgrouped by presence of malaria prevention or… (low certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.91 [0.84, 0.97]
  7 studies · 5586 participants
  Low