Persistence of the anal fissure · patients with fissure in ano
Open showed no clear difference in persistence of the anal fissure compared with closed partial lateral internal sphincterotomy (high certainty).
1 finding from 1 review
Minor incontinence to flatus · patients with fissure in ano
Open showed no clear difference in minor incontinence to flatus compared with closed partial lateral internal sphincterotomy (moderate certainty).
1 finding from 1 review
Intervention not reported
All VTE (subgroup analysis open only) · patients undergoing abdominal or pelvic surgery
The intervention probably leads to lower all VTE (subgroup analysis open only) (moderate certainty).
1 finding from 1 review
Intervention not reported
All DVT (subgroup analysis open only) · patients undergoing abdominal or pelvic surgery
The intervention probably leads to lower all DVT (subgroup analysis open only) (moderate certainty).
1 finding from 1 review
Subgroup analysis:Incidence of parastomal hernia (open surgery) ( · individuals having a stoma formation
Prosthetic mesh placement probably leads to lower subgroup analysis:Incidence of parastomal hernia (open surgery) ( compared with standard treatment (moderate certainty).
1 finding from 1 review
Conversion to open surgery · adults undergoing inguinal and femoral hernia repair
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer ‐ KRAS exon 2 MT
The intervention leads to lower grade 3 to 4 neutropenia (high certainty).
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer ‐ extended RAS WT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer ‐ extended RAS MT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer, not selected by KRAS status
The intervention probably leads to lower grade 3 to 4 neutropenia (moderate certainty).
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer, not selected by KRAS status
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer, not selected by KRAS status
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer ‐ KRAS exon 2 WT
The intervention showed no clear difference in grade 3 to 4 neutropenia (moderate certainty).
1 finding from 1 review
Intervention not reported
Grade 3 to 4 neutropenia · people with metastatic colorectal cancer
The intervention showed no clear difference in grade 3 to 4 neutropenia (moderate certainty).
1 finding from 1 review
Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy
Oral probably leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
Intraperitoneal abscess · people undergoing emergency open appendectomy for complicated appendicitis
It is very uncertain whether drainage changes intraperitoneal abscess compared with no drainage after open appendectomy (very low certainty).
1 finding from 1 review
Wound infection · people undergoing emergency open appendectomy for complicated appendicitis
It is very uncertain whether drainage changes wound infection compared with no drainage after open appendectomy (very low certainty).
1 finding from 1 review
Morbidity · people undergoing emergency open appendectomy for complicated appendicitis
Drainage may leads to higher morbidity compared with no drainage after open appendectomy (low certainty).
1 finding from 1 review