Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Childhood Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines 2022 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.01]
1 study · 200 participants
Low

Physical exercise training vs usual care

Bone mineral density · children and young adults during and after treatment for childhood cancer

1 finding from 1 review

Physical exercise training interventions for children and young adults during and after treatment for childhood cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Moderate