Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%

Lung function Mean percentage change in FEV1 · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 289 participants
Moderate

Lung function Mean percentage change in FVC (% predicted) · adults and children with cystic fibrosis

1 finding from 1 review

Nutritional status BMI · adults and children with cystic fibrosis

1 finding from 1 review

Time to first exacerbation requiring intravenous antibiotics · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 113 participants
Moderate

Antibiotic resistance patterns following treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis

The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).

1 finding from 1 review

Nephrotoxicity The percentage change in creatinine over baseline · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 245 participants
Moderate