Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

On‐demand deprescribing vs continued use

Lack of symptom control · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher lack of symptom control compared with continued use (low certainty).

1 finding from 1 review

Deprescribing versus continuation of chronic proton pump inhibitor use in adults 2017 · Cochrane Headline outcomes only
RR 1.71 [1.31, 2.21]
5 studies · 1653 participants
Low

On‐demand deprescribing vs continued use

Pill use (pills/week) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

1 finding from 1 review

Deprescribing versus continuation of chronic proton pump inhibitor use in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1152 participants
Moderate

On‐demand deprescribing vs continued use

Use of healthcare resources (cost effectiveness, time taken to fit, number of dental visits) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

The review found no eligible studies for this question.

1 finding from 1 review

Deprescribing versus continuation of chronic proton pump inhibitor use in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Deprescribing versus continuation of chronic proton pump inhibitor use in adults 2017 · Cochrane Headline outcomes only
RR 30.59 [1.84, 508.91]
1 study · 598 participants
Low

On‐demand deprescribing vs continued use

Participant satisfaction · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

It is very uncertain whether on‐demand deprescribing changes participant satisfaction compared with continued use (very low certainty).

1 finding from 1 review

Deprescribing versus continuation of chronic proton pump inhibitor use in adults 2017 · Cochrane Headline outcomes only
RR 1.82 [1.26, 2.65]
5 studies · 1653 participants
Very low