What do systematic reviews say?

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  RR 0.64 [0.26, 1.58]
  3 studies · 196 participants
  Very low

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 158 participants
  Very low

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  206 participants
  Very low