Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Multivitamin vs placebo

Average mouth pain during RAS episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in average mouth pain during RAS episodes compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
MD -0.05 [-0.71, 0.61]
1 study
GRADE not reported

Multivitamin vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in mean number of new lesions compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
MD -0.41 [-1.85, 1.03]
1 study
GRADE not reported

Multivitamin vs placebo

Duration of episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in duration of episodes compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
MD -0.33 [-2.06, 1.40]
1 study
GRADE not reported

Pentoxifylline vs multivitamin and mineral supplement

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
1 study · 29 participants
GRADE not reported

Pentoxifylline vs multivitamin and mineral supplement

Severity of oral/mucosal burning pain/sensation · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Rajendran 2006 concluded the intervention reduced pain, but pain intensity evaluations were inadequately defined and from interview data, making mean scores difficult to interpret.
1 study · 29 participants
GRADE not reported