Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Eyes and Vision

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No studies found 2 · 25%GRADE not reported 0 · 0%Very low 3 · 37.5%Low 3 · 37.5%Moderate 0 · 0%High 0 · 0%

Botulinum toxin vs observation

Improvement in ocular motility (ocular alignment ≤ 10 prism dioptres). · people with sixth nerve palsy

Botulinum toxin showed no clear difference in improvement in ocular motility (ocular alignment ≤ 10 prism dioptres). compared with observation (low certainty).

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
RR 1.19 [0.96, 1.48]
1 study · 47 participants
Low

Botulinum toxin vs observation

Secondary outcome: achievement of binocular single vision · people with sixth nerve palsy

Botulinum toxin showed no clear difference in achievement of binocular single vision (fusion and stereopsis… compared with observation (low certainty).

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
RR 1.19 [0.96, 1.48]
1 study · 47 participants
Low

Botulinum toxin vs observation

Improvement in functional ability · people with sixth nerve palsy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Botulinum toxin vs observation

Quality of life · people with sixth nerve palsy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Botulinum toxin vs observation

Adverse events. · people with sixth nerve palsy

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Low

Intervention not reported

Gabapentin up to 900 mg/day) versus baclofen (up to 30 mg/day). · people with acquired nystagmus

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Intervention not reported

3,4‐DAP (20 mg, single dose) versus placebo. Assessments made 30 minutes after taking the drug or placebo · people with acquired nystagmus

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Intervention not reported

4‐AP (10 mg, single dose) versus 3,4‐DAP (10 mg, single dose) Assessments made at 45 and 90 minutes after taking the drug · people with acquired nystagmus

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Very low