Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 4 · 57.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 42.9%High 0 · 0%

Quality of life ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Serum urate normalisation ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Function ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Withdrawals due to adverse events · participants with tophi in gout

Monthly pegloticase probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 8.19 [1.12, 59.71]
1 study · 127 participants
Moderate

Total adverse events · participants with tophi in gout

Monthly pegloticase showed no clear difference in total adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 1.05 [0.98, 1.14]
1 study · 127 participants
Moderate

Proportion with complete resolution of a target tophus · participants with tophi in gout

Monthly pegloticase showed no clear difference in proportion with complete resolution of tophi compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 2.86 [0.68, 11.97]
1 study · 79 participants
Moderate

Joint pain reduction ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found