Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
1 finding from 1 review
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · depression in adults
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).
1 finding from 1 review
Change in depressive symptoms · depression in adults
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission depression rating… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with placebo (low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission Depression rating… compared with placebo (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · depression in adults
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review