Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 1 reviews · Kidney and Transplant · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 22.7%Low 13 · 59.1%Moderate 4 · 18.2%High 0 · 0%

Antibody vs other antibody (stratified by antibody type)

Failure of acute rejection reversal · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Recurrent rejection · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in recurrent rejection compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss censored for death · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss censored for death compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss or death with a functioning graft · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss or death with a functioning graft compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Adverse effects ‐ Bacterial infection clinical assessment · kidney transplant recipients: steroid‐resistant rejection episodes

It is very uncertain whether antibody changes treatment adverse events: bacterial infection compared with other antibody (stratified by antibody type) (very low certainty).

1 finding from 1 review

Antibody (T cell) vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Antibody (T cell) showed no clear difference in graft loss or death with a functioning graft compared with steroid (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody (T cell) vs steroids

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) changes treatment adverse events: fever, chill, or malaise after drug… compared with steroid (stratified by antibody type) (very low certainty).

1 finding from 1 review

Antibody (T cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) + steroid changes graft loss or death with a functioning graft compared with steroid alone (very low certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Recurrent rejection · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in recurrent rejection compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review