Mortality Mortality at latest · heart transplant recipients
Monoclonal antibody showed no clear difference in mortality Mortality at latest compared with polyclonal antibody (low certainty).
1 finding from 1 review
Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients
Monoclonal antibody showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy compared with polyclonal antibody (low certainty).
1 finding from 1 review
Infection Number of participants diagnosed with infection · heart transplant recipients
Monoclonal antibody showed no clear difference in infection Number of participants diagnosed with infection compared with polyclonal antibody (low certainty).
1 finding from 1 review
CMV infection · heart transplant recipients
Monoclonal antibody showed no clear difference in cytomegalovirus infection Number of participants diagnosed with CMV… compared with polyclonal antibody (low certainty).
1 finding from 1 review
Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients
Monoclonal antibody showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… compared with polyclonal antibody (low certainty).
1 finding from 1 review
Cancer · heart transplant recipients
Monoclonal antibody showed no clear difference in cancer Number of participants diagnosed with cancer compared with polyclonal antibody (low certainty).
1 finding from 1 review
Pulmonary exacerbations · children (12 or over) and adults with cystic fibrosis and lung infection
Summary of findings: monoclonal antibody KB001‐A showed no clear difference in pulmonary exacerbations compared with placebo (low certainty).
1 finding from 1 review
Respiratory function number of episodes of a drop in FEV1 (unit of measurement not given) · children (12 or over) and adults with cystic fibrosis and lung infection
It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes respiratory function number of episodes of a drop in FEV1 (unit of… compared with placebo (very low certainty).
1 finding from 1 review
Number experiencing adverse effects · children (12 or over) and adults with cystic fibrosis and lung infection
It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes adverse events number of participants experiencing adverse events compared with placebo (very low certainty).
1 finding from 1 review
Need for antibiotics time to need for antibiotics · children (12 or over) and adults with cystic fibrosis and lung infection
Summary of findings: monoclonal antibody KB001‐A showed no clear difference in need for antibiotics time to need for antibiotics compared with placebo (moderate certainty).
1 finding from 1 review
QoL · children (12 or over) and adults with cystic fibrosis and lung infection
1 finding from 1 review
Sputum microbiology · children (12 or over) and adults with cystic fibrosis and lung infection
1 finding from 1 review
Inflammatory markers · children (12 or over) and adults with cystic fibrosis and lung infection
1 finding from 1 review
Failure of acute rejection reversal · kidney transplant recipients: steroid‐resistant rejection episodes
Antibody showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by antibody type) (low certainty).
1 finding from 1 review
Recurrent rejection · kidney transplant recipients: steroid‐resistant rejection episodes
Antibody showed no clear difference in recurrent rejection compared with other antibody (stratified by antibody type) (low certainty).
1 finding from 1 review
Graft loss censored for death · kidney transplant recipients: steroid‐resistant rejection episodes
Antibody showed no clear difference in graft loss censored for death compared with other antibody (stratified by antibody type) (low certainty).
1 finding from 1 review
Graft loss or death with a functioning graft · kidney transplant recipients: steroid‐resistant rejection episodes
Antibody showed no clear difference in graft loss or death with a functioning graft compared with other antibody (stratified by antibody type) (low certainty).
1 finding from 1 review
Death · kidney transplant recipients: steroid‐resistant rejection episodes
Antibody showed no clear difference in death compared with other antibody (stratified by antibody type) (low certainty).
1 finding from 1 review
Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: steroid‐resistant rejection episodes
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Adverse effects ‐ Bacterial infection clinical assessment · kidney transplant recipients: steroid‐resistant rejection episodes
It is very uncertain whether antibody changes treatment adverse events: bacterial infection compared with other antibody (stratified by antibody type) (very low certainty).
1 finding from 1 review