Findings

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Evidence found and GRADE certainty

39 questions · 39 findings · 2 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 15.4%Low 22 · 56.4%Moderate 10 · 25.6%High 1 · 2.6%

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Recurrent rejection · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in recurrent rejection compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: fever, chills, malaise after drug… compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Neurological adverse effects · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: neurological side effects compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in failure of reversal of acute rejection compared with steroid alone (moderate certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in graft loss or death with a functioning graft compared with steroid alone (moderate certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Treatment adverse events: UTI/pyelonephritis · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid probably leads to higher treatment adverse events: UTI/pyelonephritis compared with steroid alone (moderate certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Failure of acute rejection reversal · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Recurrent rejection · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in recurrent rejection compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss censored for death · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss censored for death compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Graft loss or death with a functioning graft · kidney transplant recipients: steroid‐resistant rejection episodes

Antibody showed no clear difference in graft loss or death with a functioning graft compared with other antibody (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody vs other antibody (stratified by antibody type)

Adverse effects ‐ Bacterial infection clinical assessment · kidney transplant recipients: steroid‐resistant rejection episodes

It is very uncertain whether antibody changes treatment adverse events: bacterial infection compared with other antibody (stratified by antibody type) (very low certainty).

1 finding from 1 review

Antibody (T cell) vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Antibody (T cell) showed no clear difference in graft loss or death with a functioning graft compared with steroid (stratified by antibody type) (low certainty).

1 finding from 1 review