Midline showed no clear difference in peritonitis compared with lateral insertion (moderate certainty).
Midline showed no clear difference in exit‐site/tunnel infection compared with lateral insertion (low certainty).
It is very uncertain whether midline changes catheter removal or replacement compared with lateral insertion (very low certainty).
It is very uncertain whether midline changes death (all causes) compared with lateral insertion (very low certainty).
It is very uncertain whether summary of findings table ‐ Off‐midline closure changes recurrence rate compared with tension‐free midline closure (very low certainty).
It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound infection compared with tension‐free midline closure (very low certainty).
It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound dehiscence compared with tension‐free midline closure (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether summary of findings table ‐ Off‐midline closure changes proportion of wounds healed compared with conventional midline closure (very low certainty).
Summary of findings table ‐ Off‐midline closure probably leads to lower recurrence rate compared with conventional midline closure (moderate certainty).
Summary of findings table ‐ Off‐midline closure probably leads to lower wound infection compared with conventional midline closure (moderate certainty).
Summary of findings table ‐ Off‐midline closure may leads to lower wound dehiscence compared with conventional midline closure (low certainty).
The review found no eligible studies for this question.
Summary of findings table ‐ Off‐midline closure may leads to higher proportion of wounds healed compared with tension‐free midline closure (low certainty).
Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in proportion of wounds healed compared with off‐midline closure (Limberg flap) (low certainty).