Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews · Skin

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No studies found 5 · 35.7%GRADE not reported 0 · 0%Very low 4 · 28.6%Low 1 · 7.1%Moderate 4 · 28.6%High 0 · 0%

Metformin 500 mg to 2550 mg per day vs placebo

Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin 500 mg to 2550 mg per day vs placebo

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin 500 mg to 2550 mg per day vs placebo

Proportion of participants who reported an adverse event · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 63 participants
Very low

Metformin 500 mg to 2550 mg per day vs placebo

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 264 participants
Low

Metformin 500 mg to 2550 mg per day vs placebo

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 309 participants
Moderate

Metformin 500 mg to 2550 mg per day vs placebo

Change in BMI · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 252 participants
Moderate

Metformin 500 mg to 2550 mg per day vs placebo

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether flutamide 250 mg once to twice daily changes proportion of participants who reported an adverse event compared with metformin 1275 mg to 1700 mg per day (very low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 2 [0.41, 9.71]
1 study · 40 participants
Very low

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 95 participants
Very low

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 95 participants
Moderate

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Change in BMI3 kg/m² · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 95 participants
Very low

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 55 participants
Moderate