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Evidence found and GRADE certainty

516 questions · 545 findings · 51 reviews · Gynaecology and Fertility · Headline outcomes only

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No studies found 129 · 23.7%GRADE not reported 5 · 0.9%Very low 196 · 36%Low 162 · 29.7%Moderate 51 · 9.4%High 2 · 0.4%

Metformin vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (very low certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Polyps · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial polyps compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Hyperplasia · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial hyperplasia compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + megestrol vs megestrol

Progression of endometrial hyperplasia to endometrial cancer · endometrial hyerplasia

It is very uncertain whether summary of findings table ‐ Metformin + megestrol changes progression of endometrial hyperplasia to endometrial cancer compared with megestrol (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + megestrol vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyerplasia

Summary of findings table ‐ Metformin + megestrol may leads to higher regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes regression of endometrial hyperplasia (with or without atypia) to… compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review