Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Endodontics and dental trauma

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No studies found 0 · 0%GRADE not reported 2 · 50%Very low 2 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Partial pulpotomy with one-unit longer follow-up vs Partial pulpotomy with one-unit shorter follow-up

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

In the high-risk-study-excluded sensitivity meta-regression, longer follow-up was associated with lower success.

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
Per unit increase in follow-up time · Sensitivity analysis excluding studies with high risk of bias
Meta-regression coefficient -0.36
Studies not reported
GRADE not reported

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at 12 months or more (long-term postobturation pain) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

1 finding from 1 review

Single versus multiple visits for endodontic treatment of permanent teeth 2022 · Cochrane All outcomes
12 to 18 months
Pain at 12 months or more reported by 2 studies (de Castro Rizzi-Maia 2016 at 12 months; Wong 2015 at 18 months). de Castro Rizzi-Maia 2016: no participant reported pain. Wong 2015: 1/117 single-visit vs 1/103…
2 studies
GRADE not reported

Intermediate restorative material (IRM) root-end filling vs SuperEBA

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with superEBA (very low certainty).

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
1 year or longer
RR 1.11 [0.99, 1.24]
1 study · 194 participants
Very low

Intermediate restorative material (IRM) root-end filling vs Gutta-percha

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with gutta-percha (very low certainty).

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
1 year or longer
RR 0.92 [0.80, 1.05]
1 study · 147 participants
Very low