Leflunomide vs methotrexate
Death · adults with renal vasculitis for maintenance therapy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
13 questions · 13 findings · 2 reviews · Kidney and Transplant
No studies found 7 · 53.8%GRADE not reported 0 · 0%Very low 3 · 23.1%Low 3 · 23.1%Moderate 0 · 0%High 0 · 0%
Leflunomide vs methotrexate
Kidney function · adults with renal vasculitis for maintenance therapy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Leflunomide vs methotrexate
Dialysis · adults with renal vasculitis for maintenance therapy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Leflunomide vs methotrexate
Relapse · adults with renal vasculitis for maintenance therapy
Leflunomide showed no clear difference in relapse compared with methotrexate (low certainty).
1 finding from 1 review
- RR 0.5 [0.22, 1.11]1 study · 54 participantsLow
Leflunomide vs methotrexate
Serious adverse events* · adults with renal vasculitis for maintenance therapy
Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).
1 finding from 1 review
- RR 11.81 [0.69, 203.68]1 study · 54 participantsLow
Leflunomide vs methotrexate
Infection · adults with renal vasculitis for maintenance therapy
Leflunomide showed no clear difference in infection compared with methotrexate (low certainty).
1 finding from 1 review
- RR 1.17 [0.27, 106.88]1 study · 54 participantsLow
Leflunomide vs no leflunomide regimen
End‐stage renal disease · adults and children who have IgA nephropathy proven on renal biopsy
It is very uncertain whether leflunomide regimen changes end‐stage kidney disease compared with no leflunomide regimen (very low certainty).
1 finding from 1 review
- RR 0.68 [0.17, 2.65]1 study · 85 participantsVery low
Leflunomide vs no leflunomide regimen
Complete remission · adults and children who have IgA nephropathy proven on renal biopsy
It is very uncertain whether leflunomide regimen changes complete remission compared with no leflunomide regimen (very low certainty).
1 finding from 1 review
- RR 1.08 [0.8, 1.46]4 studies · 282 participantsVery low
Leflunomide vs no leflunomide regimen
GFR loss ≥ 50% · adults and children who have IgA nephropathy proven on renal biopsy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Leflunomide vs no leflunomide regimen
Annual GFR loss (mL/min/1.73 m2) · adults and children who have IgA nephropathy proven on renal biopsy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Leflunomide vs no leflunomide regimen
Death (any cause) · adults and children who have IgA nephropathy proven on renal biopsy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Leflunomide vs no leflunomide regimen
Infection · adults and children who have IgA nephropathy proven on renal biopsy
It is very uncertain whether leflunomide regimen changes infection compared with no leflunomide regimen (very low certainty).
1 finding from 1 review
- RR 0.97 [0.45, 2.09]3 studies · 387 participantsVery low
Leflunomide vs no leflunomide regimen
Malignancy · adults and children who have IgA nephropathy proven on renal biopsy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found