Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

77 questions · 78 findings · 13 reviews · Neuromuscular

No studies found 8 · 10.3%GRADE not reported 3 · 3.8%Very low 16 · 20.5%Low 20 · 25.6%Moderate 10 · 12.8%High 21 · 26.9%

Botulinum toxin vs placebo

Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

Botulinum toxin injection showed no clear difference in participant‐reported improvement in sialorrhea in the short term… compared with placebo (low certainty).

1 finding from 1 review

Radiotherapy vs botulinum toxin

Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy vs botulinum toxin

Adverse events, reported as "negative experiences" · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).

1 finding from 1 review

BM‐MSC vs no treatment

Functional impairment · people with probable or definite amyotrophic lateral sclerosis/motor neuron disease (treated with riluzole)
2 findings from 1 review