Custom foot orthoses vs shoes
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with juvenile idiopathic arthritis and flat feet
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Findings
What do systematic reviews say?
37 questions · 38 findings · 3 reviews · Headline outcomes only
No studies found 13 · 34.2%GRADE not reported 0 · 0%Very low 3 · 7.9%Low 22 · 57.9%Moderate 0 · 0%High 0 · 0%
Custom foot orthoses vs shoes
Function or disability (measured on 0 to 100‐point FFI; 0 = no disability) · children with juvenile idiopathic arthritis and flat feet
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Custom foot orthoses vs shoes
QoL · children with juvenile idiopathic arthritis and flat feet
2 findings from 1 review
- no estimate extractedStudies not reportedLow
- no estimate extractedStudies not reportedLow
Custom foot orthoses vs shoes
Treatment success (measured on the 50FTW (seconds)) · children with juvenile idiopathic arthritis and flat feet
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Custom foot orthoses vs shoes
Withdrawals due to adverse events · children with juvenile idiopathic arthritis and flat feet
Custom foot orthoses showed no clear difference in withdrawal due to adverse events compared with shoes (low certainty).
1 finding from 1 review
- RR 0.58 [0.11, 2.94]Studies not reportedLow
Custom foot orthoses vs shoes
Adverse events · children with juvenile idiopathic arthritis and flat feet
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Custom foot orthoses vs shoes
Serious adverse events · children with juvenile idiopathic arthritis and flat feet
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Methotrexate vs placebo
OutcomesTime frame of absolute effects · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Treatment responsea · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Sustained clinically inactive diseasec · children and young people with JIA
Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in sustained clinically inactive diseaseb(12 months) compared with intra‐articular glucocorticoid alone (low certainty).
1 finding from 1 review
- RR 1.37 [0.91, 2.06]1 study · 207 participantsLow
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Function · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Pain · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Global well‐being: rated by participants · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Serious adverse events(12 months) · children and young people with JIA
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Withdrawals due to adverse events · children and young people with JIA
Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in withdrawals due to adverse events(12 months) compared with intra‐articular glucocorticoid alone (low certainty).
1 finding from 1 review
- RR 8.75 [0.48, 160.4]1 study · 207 participantsLow
Methotrexate vs alternative disease‐modifying antirheumatic drugs
OutcomesTime frame of absolute effects · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Methotrexate vs alternative disease‐modifying antirheumatic drugs
Treatment responsea · children and young people with JIA
Methotrexate showed no clear difference in treatment responsea(4 months) compared with alternative disease‐modifying antirheumatic drugs (low certainty).
1 finding from 1 review
- RR 1.4 [0.93, 2.1]1 study · 94 participantsLow
Methotrexate vs alternative disease‐modifying antirheumatic drugs
Sustained clinically inactive diseasec · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Methotrexate vs placebo
Treatment responsea · children and young people with JIA
Methotrexate may leads to higher treatment responsea(up to 6 months) compared with placebo (low certainty).
1 finding from 1 review
- RR 1.67 [1.21, 2.31]3 studies · 328 participantsLow
Methotrexate vs alternative disease‐modifying antirheumatic drugs
Function · children and young people with JIA
1 finding from 1 review
- no estimate extracted1 study · 94 participantsLow