Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 1 reviews

No studies found 1 · 9.1%GRADE not reported 10 · 90.9%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Temporomandibular disorders (TMD), TMJ arthritis/involvement and orofacial pain · Children and adolescents with juvenile idiopathic arthritis (JIA)

TMD and TMJ arthritis/involvement (and orofacial pain) were consistently reported more frequently in children/adolescents with JIA than in healthy peers, though several studies had small samples; no pooled estimate (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Developmental defects of enamel measured by any validated index · Children and adolescents with juvenile idiopathic arthritis (JIA)

A single small study suggested developmental enamel defects were more frequent in children with JIA, but the evidence is insufficient (1 study; ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Oral ulcerations · Children and adolescents with juvenile idiopathic arthritis (JIA)

A single study reported more oral ulcerations in children with JIA (5/41) than without JIA (1/41); evidence is limited to one study (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Dental maturation (tooth calcification) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Evidence on dental maturation was divergent across two studies (one found more advanced maturation in JIA, one found no difference); no clear conclusion (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Dental erosive wear · Children and adolescents with juvenile idiopathic arthritis (JIA)

No eligible studies reported dental erosive wear, so its association with JIA could not be assessed (evidence gap).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Oral health-related quality of life · Children and adolescents with juvenile idiopathic arthritis (JIA)

Evidence on OHRQoL was limited: one study found no significant difference between groups while another found orofacial symptoms affected daily life more in JIA; no pooled estimate (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Plaque index (PI) / oral hygiene · Children and adolescents with juvenile idiopathic arthritis (JIA)

Evidence on oral hygiene/dental plaque was inconsistent: several studies found higher plaque in the JIA group while others found no difference; no pooled estimate (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Periodontal conditions (gingival inflammation, bleeding, probing depth, attachment loss) were more frequently reported in children/adolescents with JIA than in healthy peers, although not all studies agreed; no pooled estimate (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Caries in primary teeth: dmft (3 years) · Children and adolescents with juvenile idiopathic arthritis (JIA)

There was no significant difference in dental caries of the primary teeth (dmft) between children with JIA and healthy peers (pooled MD -1.16, 95% CI -3.02 to 0.71; 3 cross-sectional studies; very high heterogeneity I2=87.9%; ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Dental caries in permanent teeth · Children and adolescents with juvenile idiopathic arthritis (JIA)

There was no significant difference in dental caries of the permanent teeth (DMFT) between children/adolescents with JIA and healthy peers (pooled MD -0.08, 95% CI -0.42 to 0.26; 6 cross-sectional studies; no heterogeneity I2=0%; ungraded).

1 finding from 1 review

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review