Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 51 findings · 3 reviews · Headline outcomes only

No studies found 13 · 25.5%GRADE not reported 1 · 2%Very low 5 · 9.8%Low 8 · 15.7%Moderate 19 · 37.3%High 5 · 9.8%

Intravenous midazolam vs placebo

Anterograde amnesia (defined by number of participants who recalled the procedure) · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs placebo

Allergic or anaphylactoid reaction · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs diazepam

Anxiety · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in numeric rating of anxiety or rated as anxious compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Anterograde amnesia (defined by number of participants who recalled the procedure) · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam may leads to lower anterograde amnesia (defined by number of participants who recalled… compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Disinhibition or excitation · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs diazepam

Discomfort/pain · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in discomfort/pain compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Allergic or anaphylactoid reaction · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs intravenous diazepam

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Intravenous midazolam vs intravenous diazepam

Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to stop the seizure: additional dose of… compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Intravenous midazolam vs intravenous diazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous diazepam (moderate certainty).

1 finding from 1 review