Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 33.3%High 4 · 66.7%

Intraoperative 5‐Fluorouracil vs placebo or control

Failure at 12 months Need for repeat surgery or uncontrolled IOP (usually more than 22 mm Hg) despite additional topical or systemic medications · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.68 [0.51, 0.92]
4 studies · 711 participants
High

Intraoperative 5‐Fluorouracil vs placebo or control

Mean intraocular pressure · participants with glaucoma surgery

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 711 participants
High

Intraoperative 5‐Fluorouracil vs placebo or control

Complications ‐ wound leak · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil showed no clear difference in complications ‐ wound leak compared with placebo or control (high certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 1.36 [1, 1.84]
4 studies · 711 participants
High

Intraoperative 5‐Fluorouracil vs placebo or control

Complications ‐ hypotonous maculopathy · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil showed no clear difference in complications ‐ hypotonous maculopathy compared with placebo or control (moderate certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 1.47 [0.42, 5.12]
4 studies · 711 participants
Moderate

Intraoperative 5‐Fluorouracil vs placebo or control

Complications ‐ shallow anterior chamber · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to higher complications ‐ shallow anterior chamber compared with placebo or control (high certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 1.99 [1.22, 3.22]
4 studies · 711 participants
High

Intraoperative 5‐Fluorouracil vs placebo or control

Complications ‐ epithelial toxicity · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil showed no clear difference in complications ‐ epithelial toxicity compared with placebo or control (moderate certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 1.23 [0.85, 1.77]
4 studies · 711 participants
Moderate