Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 1 · 16.7%Very low 0 · 0%Low 2 · 33.3%Moderate 2 · 33.3%High 1 · 16.7%

Intramuscular (IM) progesterone vs no treatment or placebo

Perinatal mortality · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in perinatal death compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.45 [0.6, 3.51]
6 studies · 3089 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.54 [1.06, 2.26]
2 studies · 399 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Major neurodevelopmental disability at childhood · Women with a multiple pregnancy

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intramuscular (IM) progesterone vs no treatment or placebo

Low birthweight · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in infant birthweight less than 2500 g compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.08]
5 studies · 4071 participants
Moderate

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.08 [0.75, 1.55]
5 studies · 1920 participants
Moderate

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 37 weeks compared with no treatment or placebo (high certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.05 [0.98, 1.13]
5 studies · 2010 participants
High