Farzanegan 2021 = Transbond XT + 1% chitosan + 1% TiO2 (co-intervention); Mollabashi 2022 = TiO2-only composite (1 wt%) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two small RCTs gave inconsistent results for TiO2-modified adhesives/composites on enamel demineralization (one favorable on DIAGNOdent, one no difference in mineral content); ungraded.
1 finding from 1 review
- Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes1 day to 6 months · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adultsTwo RCTs (Farzanegan 2021 n=24; Mollabashi 2022 n=40): Mollabashi reported DIAGNOdent readings significantly lower on the TiO2 side than the control side (p<0.001); Farzanegan reported no significant difference in…2 studies · 64 participantsGRADE not reported