Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

232 questions · 234 findings · 11 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 68 · 29.1%GRADE not reported 0 · 0%Very low 57 · 24.4%Low 55 · 23.5%Moderate 48 · 20.5%High 6 · 2.6%

Inhaled NO vs placebo

Frequency of pain crises in the · people with SCD

Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty).

2 findings from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin

Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

It is very uncertain whether oral ciprofloxacin and inhaled colistin changes eradication of P aeruginosa from the respiratory tract: proportion… compared with inhaled tobramycin (TNS) (very low certainty).

1 finding from 1 review