Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 1 · 14.3%GRADE not reported 1 · 14.3%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Etilefrine vs placebo

Immediate side effects of treatment (palpitations) · men and boys with SCD and stuttering priapism

It is very uncertain whether etilefrine changes immediate side effects of treatment (palpitations) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1.64 [0.62, 4.3]
1 study · 23 participants
Very low

Etilefrine vs placebo

Immediate side effects of treatment (tachycardia) · men and boys with SCD and stuttering priapism

It is very uncertain whether etilefrine changes immediate side effects of treatment (tachycardia) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 2.18 [0.71, 6.68]
1 study · 23 participants
Very low

Ephedrine vs placebo

Immediate side effects of treatment with 30 mg ephedrine (palpitations) · men and boys with SCD and stuttering priapism

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine… compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.32, 3.1]
1 study · 24 participants
Very low

Ephedrine vs placebo

Immediate side effects of treatment (tachycardia) · men and boys with SCD and stuttering priapism

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine (tachycardia) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.67 [0.13, 3.3]
1 study · 24 participants
Very low

Silboesterol vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… led to lower number of immediate and delayed postoperative bleeding episodes… compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
Immediate (<24 h) and delayed (24 h to 10 days); bleeds occurred 1, 3 or 5 days postoperatively
RD -0.22 [-0.35, -0.10]
1 study · 89 participants
GRADE not reported