Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 6 reviews · Skin

No studies found 5 · 26.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 36.8%Moderate 7 · 36.8%High 0 · 0%

Tacrolimus 0.1% vs vehicle

Primary: adverse events ‐ burning/itching at application site · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment showed no clear difference in primary: adverse events ‐ burning/itching at application site compared with vehicle (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or vitamins

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Azithromycin showed no clear difference in the proportion of participants with resolution of itch within 2… compared with placebo or vitamins (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir probably leads to lower proportion of participants with resolution of itch within 2 weeks,… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir + calamine + cetirizine vs calamine + cetirizine

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir + calamine + cetirizine may leads to higher the proportion of participants with resolution of itch within 2… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Clarithromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Clarithromycin showed no clear difference in the proportion of participants with resolution of itch within 2… compared with placebo (moderate certainty).

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir showed no clear difference in the proportion of participants with resolution of itch within 2… compared with erythromycin (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Clarithromycin vs placebo

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Erythromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary outcome 1: participant‐ or parent‐rated symptoms of eczema (SCORAD part C) at the end of active treatment Visual analogue scale for itch and sleep disturbance ranging from 0 to 10 for each symptom and combined ranging from 0 to 20. The hig... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review