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Evidence found and GRADE certainty

12 questions · 12 findings · 3 reviews

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No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 2 · 16.7%Low 6 · 50%Moderate 2 · 16.7%High 0 · 0%

Hydroxyzine 25 mg vs placebo

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Hydroxyzine 25 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Number of children with clinical adverse event: behavioural change · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in number of children with clinical adverse event: behavioural change compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Number of children with clinical adverse event: nausea or vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in number of children with clinical adverse event: nausea or vomiting compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty).

1 finding from 1 review

Loratadine 10 mg vs hydroxyzine 25 mg

Complete suppression of urticaria: short‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

1 finding from 1 review