Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Eyes and Vision

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Oral long‐chain omega‐3 PUFAs vs oral omega‐6 PUFAs

Aqueous tear production · people with dry eyea

Oral long‐chain omega‐3 PUFAs showed no clear difference in change in Schirmer test (aqueous tear production, measured in mm/5… compared with oral omega‐6 PUFAs (low certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 2.6
5 studies · 1205 participants
Low

Oral long‐chain omega‐3 PUFAs vs oral omega‐6 PUFAs

Tear film stability · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1205 participants
Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Tear film stability · people with dry eyea

Combined oral omega‐3 and omega‐6 PUFAs showed no clear difference in change in tear film stability, measured using tear break‐up time… compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.55
4 studies · 455 participants
Moderate

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Aqueous tear production · people with dry eyea

Combined oral omega‐3 and omega‐6 PUFAs showed no clear difference in schirmer test (aqueous tear production, measured in mm/5 min, with… compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.66
4 studies · 455 participants
Moderate

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Aqueous tear production · people with dry eyea

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in Schirmer test (aqueous tear production, measured in mm/5… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.68
7 studies · 1730 participants
Moderate

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Tear film stability · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1640 participants
Low