Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

121 questions · 139 findings · 21 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 42 · 30.2%GRADE not reported 6 · 4.3%Very low 20 · 14.4%Low 38 · 27.3%Moderate 15 · 10.8%High 18 · 12.9%

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 19,475 (3 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in any cancer risk No. of participants: 19,475 (3 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Mortality: all cancers · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes cancer mortality risk No. of participants: 183,863 (7 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review