Findings

What do systematic reviews say?

5 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 3 · 50%Very low 3 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Premature ovarian failure · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes pregnancy compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 3 [0.13, 70.3]
1 study · 50 participants
Very low

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Ovulation · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Adverse events · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes menstruation recovery or maintenance: compared with chemotherapy alone (very low certainty).

2 findings from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 1 [0.76, 1.32]
1 study · 50 participants
Very low
Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 0.93 [0.56, 1.55]
1 study · 50 participants
Very low