Findings

What do systematic reviews say?

4 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Days of unsanctioned opioid use · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance showed no clear difference in days of unsanctioned opioid use (as number of days/30 or days/7) compared with placebo, detoxification only or psychological treatment… (low certainty).

1 finding from 1 review

Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
SMD 0.19
3 studies · 205 participants
Low

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Opioid use · pharmaceutical opioid dependent people

It is very uncertain whether full or partial opioid agonist maintenance changes self‐reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (very low certainty).

2 findings from 1 review

Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
RR 0.63 [0.39, 1.01]
4 studies · 276 participants
Very low
Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
RR 0.66 [0.52, 0.84]
4 studies · 270 participants
Low

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Adverse events · pharmaceutical opioid dependent people

It is very uncertain whether full or partial opioid agonist maintenance changes adverse events compared with placebo, detoxification only or psychological treatment… (very low certainty).

1 finding from 1 review

Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
RR 0.5 [0.07, 3.48]
3 studies · 252 participants
Very low

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Retention in treatment · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance probably leads to higher retention: proportion of participants retained in treatment compared with placebo, detoxification only or psychological treatment… (moderate certainty).

1 finding from 1 review

Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only
RR 3.02 [1.73, 5.27]
4 studies · 333 participants
Moderate