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Evidence found and GRADE certainty

27 questions · 27 findings · 2 reviews · Developmental, Psychosocial and Learning Problems

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 3.7%Low 5 · 18.5%Moderate 14 · 51.9%High 7 · 25.9%

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Relapse during intervention defined as admission to inpatient therapeutic care, remain wasted, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) leads to lower relapse during intervention defined as admission to inpatient… compared with RUTF using an alternative formulation (high certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) showed no clear difference in mortality during intervention compared with RUTF using an alternative formulation (moderate certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Recovery during intervention defined as weight gain ≥ 15% in relation to baseline weight, absence of complications and oedema, and MUAC > 110 mm in 2 studies; MUAC > 12.4 cm without oedema in 1 study; WHZ ≥ 80% for two consecutive visits in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) showed no clear difference in recovery during intervention defined as weight gain ≥ 15% in… compared with RUTF using an alternative formulation (high certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Progression to SAM · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in progression to SAM compared with blended foods (full dose) (high certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Has died · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in died compared with blended foods (full dose) (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Defaulted · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in defaulted compared with blended foods (full dose) (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Vomiting · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) may leads to higher vomiting compared with blended foods (full dose) (low certainty).

1 finding from 1 review