Findings

What do systematic reviews say?

21 questions · 21 findings · 1 reviews

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No studies found 6 · 28.6%GRADE not reported 0 · 0%Very low 7 · 33.3%Low 5 · 23.8%Moderate 2 · 9.5%High 1 · 4.8%

Flutamide 250 mg b.i.d. vs placebo

Proportion of participants who reported an adverse event · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Very low

Flutamide 250 mg b.i.d. vs placebo

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Very low

Flutamide 250 mg b.i.d. vs placebo

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Low

Flutamide 250 mg b.i.d. vs placebo

Change in BMI · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Flutamide 250 mg b.i.d. vs placebo

Improvement of other clinical signs of hyperandrogenism Mean number of menses in previous 6 months Scale from: 0 to 6 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Flutamide 250 mg b.i.d. vs placebo

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Flutamide 250 mg b.i.d. may leads to higher participant‐reported improvement of hirsutism 4‐point Likert scale compared with placebo (low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 17 [1.11, 259.87]
1 study · 20 participants
Low

Flutamide 250 mg b.i.d. vs placebo

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Flutamide 250 mg once to b.i.d. showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with spironolactone 100 mg (low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 2 [0.88, 4.54]
1 study · 20 participants
Low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Proportion of participants who reported an adverse event · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Very low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Moderate

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Change in BMI ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Finasteride 5 mg showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with flutamide 250 mg once to b.i.d. (low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 0.63 [0.31, 1.25]
1 study · 20 participants
Low

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether finasteride 5 mg changes proportion of participants who reported an adverse event compared with flutamide 250 mg once to b.i.d. (very low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 3.87 [0.57, 26.24]
3 studies · 115 participants
Very low

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 226 participants
Very low

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 226 participants
Moderate

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Change in BMI ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found