Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Fibrinolytics vs placebo

Mortality. · adult parapneumonic effusions and empyema

Fibrinolytics showed no clear difference in mortality. compared with placebo (moderate certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 1.16 [0.71, 1.91]
8 studies · 867 participants
Moderate

Fibrinolytics vs placebo

Referral for thoracic surgery (open or thorascopic) · adult parapneumonic effusions and empyema

Fibrinolytics may leads to lower referral for thoracic surgery. compared with placebo (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 0.37 [0.21, 0.68]
8 studies · 897 participants
Low

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 0.16 [0.05, 0.58]
7 studies · 769 participants
Very low

Fibrinolytics vs placebo

Serious adverse events · adult parapneumonic effusions and empyema

Fibrinolytics showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 1.28 [0.36, 4.57]
9 studies · 935 participants
Low