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Evidence found and GRADE certainty

33 questions · 33 findings · 2 reviews · Musculoskeletal · Headline outcomes only

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No studies found 2 · 6.1%GRADE not reported 3 · 9.1%Very low 0 · 0%Low 7 · 21.2%Moderate 10 · 30.3%High 11 · 33.3%

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) + DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (10 mg) · participants with rheumatoid arthritis

The intervention leads to lower etanercept (10 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept + DMARD vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. Etanercept · participants with rheumatoid arthritis

The intervention probably leads to higher etanercept + DMARD vs. Etanercept (moderate certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis
1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Remission · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in remission (number of patients with remission) compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Durable remission · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in durable remission compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Major relapse · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in major relapse compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Disease flare · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in disease flare compared with standard therapy with placebo (moderate certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Any adverse event · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in any adverse event compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Any severe or serious AE (grade 3, 4 or 5) · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in any severe or serious AE (grade 3, 4 or 5) compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Withdrawals due to adverse events · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy may leads to higher any withdrawals due to AE compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

MortalityNumber of participants: 285(2 RCTs) WGET 2005 · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in mortalityNumber of participants: 285(2 RCTs) WGET 2005 compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology 50% improvement criteria · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention probably leads to higher ACR50 American College of Rheumatology 50% improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Reduction in disability score Health Assessment Questionnaire (mean improvement from baseline). Scale from: 0 to 3 · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Intervention not reported

Radiographic progression Total Sharp Score · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review