Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 68 findings · 7 reviews · Headline outcomes only

No studies found 27 · 39.7%GRADE not reported 3 · 4.4%Very low 0 · 0%Low 9 · 13.2%Moderate 14 · 20.6%High 15 · 22.1%

Etanercept vs no etanercept

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs corticosteroids

Disease‐specific mortality ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

Etanercept showed no clear difference in disease‐specific mortality (time to compared with corticosteroids (low certainty).

1 finding from 1 review

Etanercept vs corticosteroids

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs intravenous immunoglobulin (IVIG)

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review