Findings

What do systematic reviews say?

24 questions · 24 findings · 4 reviews · Skin

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No studies found 13 · 54.2%GRADE not reported 0 · 0%Very low 2 · 8.3%Low 5 · 20.8%Moderate 4 · 16.7%High 0 · 0%

Erythromycin vs placebo

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Moderate

Erythromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Erythromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo (low certainty).

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
RR 4.02 [0.28, 56.61]
2 studies · 86 participants
Low

Erythromycin vs placebo

Adverse events: minor gastrointestinal symptoms · pityriasis rosea

Erythromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
RR 2 [0.2, 20.04]
1 study · 34 participants
Moderate

Erythromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs placebo

Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Moderate

Erythromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs no treatment

Relapse · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs no treatment

Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs no treatment

Proportion of participants with adverse events and severe adverse events · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs no treatment

Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs no treatment

Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzoyl peroxide vs erythromycin

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzoyl peroxide vs erythromycin

Withdrawals due to adverse outcomes · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (medium‐term data) Treatment… compared with erythromycin (very low certainty).

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
RR 1 [0.07, 15.26]
1 study · 60 participants
Very low

Benzoyl peroxide vs erythromycin

Adverse event data · participants with acne

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Very low

Nicotinamide vs erythromycin

Participants' global self‐assessment of acne improvement · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Nicotinamide vs erythromycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with erythromycin (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.4 [0.46, 4.22]
1 study · 158 participants
Low

Nicotinamide vs erythromycin

Minor adverse events · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Nicotinamide vs erythromycin

Quality of life · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acyclovir vs erythromycin

Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate