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Evidence found and GRADE certainty

4 questions · 4 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 100%High 0 · 0%

Epinephrine vs epinephrine and any second endoscopic method

Recurrent and persistent bleeding overall rates with or without second‐look endoscopy Rebleeding (persistent or recurrent bleeding) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower recurrent and persistent bleeding overall rates with or without… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Surgery rate Number requiring emergency surgery · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower surgery rate Number requiring emergency surgery compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Mortality rate Number of deaths (30‐day mortality or in‐hospital mortality) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower mortality rate Number of deaths (30‐day mortality or in‐hospital… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Adverse effects of endoscopy therapy Adverse effects · patients with high‐risk bleeding ulcers

Epinephrine probably leads to higher adverse effects of endoscopy therapy Adverse effects compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review