Findings

What do systematic reviews say?

105 questions · 112 findings · 1 reviews · All outcomes

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No studies found 39 · 34.8%GRADE not reported 16 · 14.3%Very low 30 · 26.8%Low 23 · 20.5%Moderate 4 · 3.6%High 0 · 0%

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% lidocaine, 1:50,000 epinephrine changes success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 0.99 [0.88, 1.12]
7 studies · 210 participants
Very low

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
'100% success' (lidocaine 1:100,000 vs 1:50,000): infraorbital block - Berberich 2009 40/40 vs 40/40; mandibular BI - Dagher 1997 30/30, Yonchak 2001 40/40; IANB - Yared 1997 30/30, Wali 2010 30/30. Both 100% successful.
5 studies · 170 participants
GRADE not reported

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:80,000 epinephrine

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
'100% success': mandibular BI - Dagher 1997 30/30 vs 30/30; IANB - Yared 1997 30/30 vs 30/30. Both 100% successful; no meta-analysis.
2 studies · 60 participants
GRADE not reported

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:80,000 epinephrine

It is very uncertain whether 2% lidocaine, 1:50,000 epinephrine changes success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:80,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 0.81 [0.65, 1.01]
2 studies · 60 participants
Very low

2% lidocaine, 1:80,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

It is very uncertain whether 2% lidocaine, 1:80,000 epinephrine changes success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 1.27 [1.01, 1.59]
2 studies · 60 participants
Very low

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% lidocaine, 1:50,000 epinephrine changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
MD -0.44 [-1.66, 0.79]
4 studies · 92 participants
Very low

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found
Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: See comment; 147 participants, 147 interventions (2 studies); unclear whether data relate to just solution deposition. Not pooled/graded.
2 studies · 147 participants
GRADE not reported

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

2 findings from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: See comment (orphan study); 86 participants, 172 interventions (1 study). Not pooled/graded.
1 study · 86 participants
GRADE not reported
Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: See comment (orphan study; exact time of follow-up not reported); 86 participants, 172 interventions (1 study). Not pooled/graded.
1 study · 86 participants
GRADE not reported

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) compared with 4% articaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
MD -8.98 [-15.17, -2.79]
5 studies · 162 participants
Very low

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of diseased pulps with irreversible pulpitis) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine may leads to higher success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
10 minutes post-injection to end of clinical procedure
RR 1.6 [1.1, 2.32]
4 studies · 203 participants
Low

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Participants' experience of the procedures · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
No data from the included studies were available.
0 studies
No studies found

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Adverse effects: allergy to local anaesthetic · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
MD -0.23 [-0.45, -0.01]
6 studies · 637 participants
Very low

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
MD 10.33 [-22.08, 42.74]
2 studies · 40 participants
Very low

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes success of local anaesthesia (soft tissue, self-reported) compared with 2% mepivacaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 1.07 [0.73, 1.59]
2 studies · 68 participants
Very low

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

2 findings from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: See comment (orphan study; unclear whether data relate to just solution deposition; SDs not reported); 18 participants, 36 interventions (1 study). Not pooled/graded.
1 study · 18 participants
GRADE not reported
Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found