Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 3 · 37.5%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Ephedrine vs phenylephrine

Maternal hypotension requiring intervention · women having spinal anaesthesia for caesarean section

It is very uncertain whether ephedrine changes maternal hypotension requiring intervention compared with phenylephrine (very low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 0.92 [0.71, 1.18]
8 studies · 401 participants
Very low

Ephedrine vs phenylephrine

Maternal hypertension requiring intervention · women having spinal anaesthesia for caesarean section

Ephedrine showed no clear difference in maternal hypertension requiring intervention compared with phenylephrine (low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 1.72 [0.71, 4.16]
2 studies · 118 participants
Low

Ephedrine vs phenylephrine

Maternal bradycardia requiring intervention · women having spinal anaesthesia for caesarean section

Ephedrine may leads to lower maternal bradycardia requiring intervention compared with phenylephrine (low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 0.37 [0.21, 0.64]
5 studies · 304 participants
Low

Ephedrine vs phenylephrine

Maternal nausea and/or vomiting · women having spinal anaesthesia for caesarean section

It is very uncertain whether ephedrine changes maternal nausea and/or vomiting compared with phenylephrine (very low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 0.76 [0.39, 1.49]
4 studies · 204 participants
Very low

Ephedrine vs phenylephrine

Neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 · women having spinal anaesthesia for caesarean section

Ephedrine showed no clear difference in neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 compared with phenylephrine (low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 0.89 [0.07, 12]
3 studies · 175 participants
Low

Ephedrine vs phenylephrine

Neonatal Apgar score < 8 at 5 minutes · women having spinal anaesthesia for caesarean section

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 321 participants
Low

Ephedrine vs phenylephrine

Admission to neonatal intensive care unit · women having spinal anaesthesia for caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Ephedrine vs phenylephrine · women having spinal anaesthesia for caesarean section

It is very uncertain whether the intervention changes ephedrine vs phenylephrine (very low certainty).

1 finding from 1 review

Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
RR 0.92 [0.71, 1.18]
8 studies · 401 participants
Very low