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Evidence found and GRADE certainty

5 questions · 6 findings · 2 reviews · Oral medicine and oral cancer · All outcomes

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No studies found 1 · 16.7%GRADE not reported 4 · 66.7%Very low 1 · 16.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single dose) vs Granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple doses)

Normalcy of diet (total parenteral nutrition) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.

1 finding from 1 review

GM-CSF vs placebo or no treatment

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo; GRADE not reported.

1 finding from 1 review

Epidermal growth factor (EGF), oral spray vs placebo

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Epidermal growth factor (EGF), oral spray showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Normalcy of diet (total parenteral nutrition) · All patients with cancer who are receiving treatment

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes normalcy of diet (days of total parenteral nutrition, TPN) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).

2 findings from 1 review