Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 40%High 2 · 40%

Stroke · patients with hypertension

Enalapril plus folic acid leads to lower stroke compared with enalapril (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.79 [0.68, 0.93]
1 study · 20702 participants
High

First unstable angina pectoris episode requiring hospitalisation · patients with hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Death from any cause · patients with hypertension

Enalapril plus folic acid showed no clear difference in death from any cause compared with enalapril (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.94 [0.81, 1.1]
1 study · 20702 participants
High

Serious adverse event (cancer) · patients with hypertension

Enalapril plus folic acid showed no clear difference in serious adverse event (cancer) compared with enalapril (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.96 [0.71, 1.31]
1 study · 20243 participants
Moderate

Myocardial infarction · patients with hypertension

Enalapril plus folic acid showed no clear difference in myocardial infarction compared with enalapril (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 1.04 [0.6, 1.82]
1 study · 20702 participants
Moderate