Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 25%High 3 · 75%

Efinaconazole 10% solution vs vehicle

Proportion of participants with complete cure · People with fungal infections of the toenails

Efinaconazole 10% solution leads to higher complete cure: 40 to 52 weeks compared with vehicle (high certainty).

1 finding from 1 review

Topical and device‐based treatments for fungal infections of the toenails 2020 · Cochrane Headline outcomes only
RR 3.54 [2.24, 5.6]
3 studies · 1716 participants
High

Efinaconazole 10% solution vs vehicle

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Efinaconazole 10% solution leads to higher adverse events (collected over the course of the studies; they are… compared with vehicle (high certainty).

1 finding from 1 review

Topical and device‐based treatments for fungal infections of the toenails 2020 · Cochrane Headline outcomes only
RR 1.1 [1.01, 1.2]
3 studies · 1701 participants
High

Efinaconazole 10% solution vs vehicle

Mycological cure · People with fungal infections of the toenails

Efinaconazole 10% solution probably leads to higher mycological cure: 40 to 52 weeks compared with vehicle (moderate certainty).

1 finding from 1 review

Topical and device‐based treatments for fungal infections of the toenails 2020 · Cochrane Headline outcomes only
RR 2.31 [1.08, 4.94]
3 studies · 1716 participants
Moderate

Efinaconazole 10% solution vs vehicle

Cure · People with fungal infections of the toenails

Efinaconazole 10% solution leads to higher clinical cure: 40 to 52 weeks compared with vehicle (high certainty).

1 finding from 1 review

Topical and device‐based treatments for fungal infections of the toenails 2020 · Cochrane Headline outcomes only
RR 3.07 [2.08, 4.53]
2 studies · 1655 participants
High