Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 47 findings · 7 reviews · Kidney and Transplant

No studies found 10 · 21.3%GRADE not reported 0 · 0%Very low 8 · 17%Low 19 · 40.4%Moderate 9 · 19.1%High 1 · 2.1%

Endoscopic injection treatment vs antibiotics alone

Febrile UTI by 1 to 2 years: endoscopic correction + antibiotics versus antibiotics alone · primary VUR

Endoscopic injection treatment showed no clear difference in febrile UTI by 1 to 2 years: endoscopic correction + antibiotics… compared with antibiotics alone (low certainty).

1 finding from 1 review

Endoscopic injection treatment vs antibiotics alone

Total new and progressive Renal parenchymal abnormalities on DMSA scan at 1 to 2 years: endoscopic correction + antibiotics versus antibiotics alone (unit of analysis: children) · primary VUR

Endoscopic injection treatment showed no clear difference in total new and progressive Renal parenchymal abnormalities on DMSA… compared with antibiotics alone (low certainty).

1 finding from 1 review

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Cure: successful eradication of the infection · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics alone changes cure: successful eradication of the infection compared with systematic antibiotics plus antibiotic lock solution (very low certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

New renal parenchymal defects (scars and thinning) on IVP: unit of analysis (children) at 4 to 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

Surgical reimplantation of ureters plus antibiotics showed no clear difference in new renal parenchymal defects (scars and thinning) on IVP: unit of… compared with antibiotics alone (moderate certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

Correction of VUR: unit of analysis (children) after 3 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

It is very uncertain whether surgical reimplantation of ureters plus antibiotics changes correction of VUR: unit of analysis (children) after 3 years:… compared with antibiotics alone (very low certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

Febrile UTI by 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

Surgical reimplantation of ureters plus antibiotics probably leads to lower febrile UTI by 5 years: surgical correction + antibiotics versus… compared with antibiotics alone (moderate certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in failure of reversal of acute rejection compared with steroid alone (moderate certainty).

1 finding from 1 review

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: diabetes or hyperglycaemia · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: diabetes or hyperglycaemia compared with oral steroids alone (low certainty).

1 finding from 1 review