What do systematic reviews say?

Any intervention for KCOT (e.g. enucleation), alone or combined with an adjunctive therapy (ostectomy, cryotherapy, or Carnoy's solution) vs A different intervention (e.g. enucleation versus marsupialisation), or the same surgical intervention without the adjunctive therapy

The review found no eligible studies for this question.

• Interventions for the treatment of keratocystic odontogenic tumours 2015 · Cochrane All outcomes
  No randomised controlled trials that met the inclusion criteria were identified. In view of the fact that no studies were identified, no data were available for analysis.
  0 studies
  No studies found

Platelet-rich fibrin after bone surgery vs Bone surgery alone

It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity and absence of infection) compared with bone surgery alone (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  1 year
  RR 1.05 [0.90, 1.22]
  1 study · 47 participants
  Very low

Platelet-rich fibrin after bone surgery vs Bone surgery alone

It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  1 year
  RR 1.60 [1.04, 2.46]
  1 study · 47 participants
  Very low

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
  1 study · 26 participants
  Very low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

The review found no eligible studies for this question.

• Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Transbuccal miniplate combined with intraoral approach vs Intraoral approach alone

Transbuccal miniplate combined with intraoral approach showed no clear difference in post-operative infection (persistent) compared with intraoral approach alone; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  3 months · Angle of mandible only
  RR 0.47 [0.20, 1.09]
  1 study · 138 participants
  GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound infection compared with traditional iliac bone graft alone; GRADE not reported.

• Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes

  At least 3 months
  RR 3.23 [0.14, 100]
  1 study · 27 participants
  GRADE not reported