Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

34 questions · 34 findings · 2 reviews · Schizophrenia

No studies found 2 · 5.9%GRADE not reported 9 · 26.5%Very low 0 · 0%Low 5 · 14.7%Moderate 9 · 26.5%High 9 · 26.5%

Droperidol vs haloperidol

Adverse effects ‐ cardiovascular ‐ hypotension/desaturation · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ cardiovascular ‐ hypotension/desaturation compared with haloperidol (low certainty).

1 finding from 1 review

Droperidol vs haloperidol

Mental state: mean score by 13 days (Scale for Quantification of Psychotic Symptom Severity, high = poor) · acute psychosis

Droperidol showed no clear difference in mental state: mean score by 13 days (Scale for Quantification of… compared with haloperidol (low certainty).

1 finding from 1 review

Droperidol vs midazolam

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol showed no clear difference in global state: use of additional medication ‐ by 60 minutes after… compared with midazolam (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with placebo (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Tranquillisation or asleep: tranquillised/asleep ‐ by around 30 minutes · acute psychosis

Droperidol showed no clear difference in tranquillisation or asleep: tranquillised/asleep ‐ by around 30… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with olanzapine (high certainty).

1 finding from 1 review