Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Musculoskeletal · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Pain 10‐cm VAS scale (median · participants with osteoarthritis of the knee or hip

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 524 participants
Moderate

Function WOMAC function (range 0 to 10) (median · participants with osteoarthritis of the knee or hip

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 517 participants
Moderate

Minimum joint space width ( · participants with osteoarthritis of the knee or hip

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 361 participants
Moderate

Number of participants experiencing any adverse event ( · participants with osteoarthritis of the knee or hip

The intervention may leads to higher number of participants experiencing any adverse event ( (low certainty).

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
RR 1.36 [1.08, 1.72]
1 study · 232 participants
Low

Number of participants withdrawn due to adverse events (median · participants with osteoarthritis of the knee or hip

The intervention may leads to higher number of participants withdrawn due to adverse events (median (low certainty).

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
RR 2.28 [1.06, 4.9]
2 studies · 663 participants
Low

Number of participants experiencing any serious adverse event (median · participants with osteoarthritis of the knee or hip

The intervention showed no clear difference in number of participants experiencing any serious adverse event (median (low certainty).

1 finding from 1 review

Doxycycline for osteoarthritis of the knee or hip 2012 · Cochrane Headline outcomes only
RR 1.07 [0.68, 1.68]
2 studies · 663 participants
Low